International Review of Ophthalmology ›› 2022, Vol. 46 ›› Issue (5): 409-414.doi: 10.3760/ cma.j.issn.1673-5803.2022.05.005

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Basic fibroblast growth factor and its application on ophthalmological research

Jin Bihui，Li Guigang   

  1. Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • Received:2022-02-13 Online:2022-10-22 Published:2022-11-04
  • Contact: Li Guigang，Email：guigli@163.com E-mail:guigli@163.com
  • Supported by:
    Global Talents Recruitment Program of Science and Technology Ministry of China (G2022154028L); National Natural Science Foundation of China (82070936); National Health Commission of Hubei Province Project (WJ2021ZH0005); Subject Construction Foundation of Finance Department of Hubei (42000022815T000000102); High Level Foreign Expert Project of Science and Technology Department of Hubei Province (2022EGD020)

Abstract: Basic fibroblast growth factor (bFGF) is a multifunctional signal molecule widely existing in the eye, such as lens epithelial cells, trabecular meshwork cells, retinal pigment epithelial cells and so on. It mainly plays a role in protecting cells, promoting cell proliferation and maintaining the characteristics of stem cells in basic research. At present, it is commonly used in the treatment of keratitis, corneal epithelial defect, corneal ulcer, corneal surgery and dry eye. bFGF plays a role in the stem cell therapy of limbal stem cell deficiency because it can promote the proliferation of limbal niche cells. But the specific mechanism is not clear and needs further research.(Int Rev Ophthalmol, 2022, 46: 409-414)

Key words: basic fibroblast growth factor, stem cell